Linda Crnic Institute
for Down Syndrome

The Global Down Syndrome Foundation provides fundraising, education, awareness and government advocacy for the Linda Crnic Institute for Down Syndrome.

Established in 2008, the Linda Crnic Institute for Down Syndrome is the first academic home for Down syndrome research in the United States. The mission of the Crnic Institute is to significantly improve the lives of people with Down syndrome by eradicating the medical and cognitive ill effects associated with the condition.

Learn more about the Linda Crnic Institute.
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  • Jamie Foxx and DeOndra Dixon help launch Down Syndrome World magazine
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    Jamie Foxx and DeOndra Dixon Help Launch
    "Down Syndrome World" Quarterly Magazine

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    Be Beautiful Be Yourself Fashion Show Breaks Record by Raising $1.9 Million

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    Celebrities Shine a National Spotlight
    on Global Down Syndrome Foundation

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    Q&A: Catching Up with Award-Winning Actor John C. McGinley

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$5 Million Dollar NIH / NIA Alzheimer’s and Down Syndrome Grant Announced!
The Global Down Syndrome Foundation is pleased to announce a new grant opportunity from the National Institute of Aging. The 2 grants totaling $5 million dollars will be awarded in late 2015. The goal of this funding opportunity is to enable the longitudinal progression of Alzheimer’s disease in adults with Down Syndrome using clinical, cognitive, imaging, genetic and biochemical biomarkers.


Global, NDSC combat discrimination against people with Down syndrome
The Global Down Syndrome Foundation and the National Down Syndrome Congress are outraged and saddened by recent public comments by the British author Richard Dawkins.
Global executive director Michelle Sie Whitten said: “It is amazing to me in the 21st century that there is so much misinformation and discrimination against people with Down syndrome. … The fact is people with Down syndrome can and do live long, happy and productive lives.”


Bill Signing
Alzheimer’s initiative receives $250,000 from state of Colorado
The Global Down Syndrome Foundation’s Alzheimer’s disease initiative received a big boost from the state of Colorado this year when Governor John Hickenlooper signed a bill passed by the state legislature that allocates $250,000 to the first Alzheimer’s disease research & clinical center in Colorado.


Statement from Michelle Sie Whitten about Thai surrogacy case
The discrimination against people with Down syndrome, even in developed nations, is profound. The abandonment of a surrogate twin boy with Down syndrome to life or death in Thailand clearly underscores this.
The reality is the condition is almost completely different from what it was just 20 years ago. For example, the lifespan of a person with Down syndrome in the 1980s was 28 years old, and today it is nearly 60. And according to a national U.S. poll commissioned by the Global Down Syndrome Foundation, over three-quarters of Americans believe people with Down syndrome have the right to vote, buy a home and get married, with 97 percent of Americans agreeing that people with Down syndrome should have the chance to hold a job and deserve fundamental human and civil rights.


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Linda Crnic Institute for Down Syndrome
The Leader in scientific research benefiting people with Down syndrome

Meet the Crnic Institute Supergroup 2013 Grant Recipients

V. Balasubramaniam, M.D.
Sleep apnea and Down syndrome
Examine the effect of sleep apnea on vascular stem cells in people with Down syndrome
Christopher Link, Ph.D.
Genetic understanding of Down syndrome
Determine which genes have altered expression due to Trisomy 21
James DeGregori, Ph.D.
Leukemia and Down syndrome
Study increase in leukemia incidence and other problems with blood cell production, including reduced immunity
Karl Pfenninger, M.D.
Cognition and Down syndrome
Study causes of intellectual disability associated with Down syndrome, specifically the APP protein
Robin Dowell, Ph.D.
Genetic understanding of Down syndrome
Understand how Trisomy 21 affects the behavior of key proteins involved in regulating expression
Tamim H. Shaikh, Ph.D.
Autism and Down syndrome
Research genetic modifiers of autism spectrum disorders in patients with Down syndrome
Joaquin Espinosa, Ph.D.
Genetic understanding of Down syndrome
Identify genes whose function is essential in trisomic cells yet dispensable in cells with only two copies of chromosome 21
Richard Spritz, M.D.
Autoimmune disorders and Down syndrome
Analyze autoimmunity genetics in Down syndrome — thyroid disease, celiac disease, type 1 diabetes and rheumatoid arthritis
Fran Hickey, M.D.
Anesthesia and Down syndrome
Provide information to improve management of post-operative pain and sedation in children with Down syndrome
Ding Xue, Ph.D.
Alzheimer’s disease and Down syndrome
Study the roles of presenilin and ubiquilin in developing treatments for Alzheimer’s disease in patients with Down syndrome
Kevin Jones, Ph.D.
Gene regulation and Down syndrome
Test whether increasing the abundance of the BDNF protein can prevent Down syndrome pathology in a mouse model
Michael Yeager, Ph.D.
Autoimmune disorders and Down syndrome
Understand immune system disturbances in individuals with Down syndrome and drive development of newer therapies
Matthew Kennedy, Ph.D.
Alzheimer’s disease and Down syndrome
Investigate how increased beta-amyloid production causes synapse loss in hope of finding targets for future therapies
Rui Yi, Ph.D.
Genetic understanding of Down syndrome
Determine the effect of gene dosage imbalance on activity in trisomic embryonic stem cells

Meet the full Supergroup