Linda Crnic Institute
for Down Syndrome

The Global Down Syndrome Foundation provides fundraising, education, awareness and government advocacy for the Linda Crnic Institute for Down Syndrome.

Established in 2008, the Linda Crnic Institute for Down Syndrome is the first academic home for Down syndrome research in the United States. The mission of the Crnic Institute is to significantly improve the lives of people with Down syndrome by eradicating the medical and cognitive ill effects associated with the condition.

Learn more about the Linda Crnic Institute.
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Keep up with research news, upcoming programs, events and educational conferences.

  • 2014 Global Down Syndrome Educational Grant Recipients Announced at NDSC Convention
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    2014 Global Down Syndrome Educational Grant Recipients Announced at NDSC Convention

  • Global Down Syndrome Foundation Dare to Play Soccer - Save the Date!
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    Global Down Syndrome Foundation Dare to Play Soccer - Save the Date!

  • 2014 Be Beautiful Be Yourself DC Gala
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    The 2014 Be Beautiful Be Yourself DC Gala Photos are now online!

  • Connor Long shows that "Down Syndrome's Got Muscle"
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    Join the MILLION CLICK MARCH and Show the World That "Down Syndrome's Got Muscle"

  • Crnic Institute Awards $1.26 Million in 2014 Grand Challenge Grants
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    BioFrontiers Sie Fellowship - Research Will Focus on Improving the Lives of People with Down syndrome

  • DeOndra Dixon, the First Global Down Syndrome Foundation Ambassador
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    Meet DeOndra Dixon, Global Down Syndrome Foundation Ambassador

Blog

University of Colorado BioFrontiers Institute

CU’s BioFrontiers Institute Launches Sie Post-doctoral Fellowship Program
The BioFrontiers Institute at the University of Colorado launched its inaugural Sie Post-doctoral Fellowship Program in affiliation with the Linda Crnic Institute for Down Syndrome on the Anschutz Medical Campus. The program will fund three post-doctoral researchers, Sie Fellows, who will focus on research that will improve the lives of individuals with Down syndrome.
The Sie Fellows research is co-funded by the BioFrontiers Institute and the Anna and John J. Sie Foundation. Every two years, three Sie Fellows will be selected from a competitive grant process and will receive between $71,000 and $85,000 a year for two years.

 

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Join Global Down Syndrome Foundation at NDSC Convention
Visit Us at the NDSC Convention! Catch up on the latest Global News! Sign up for our drawings and learn about our great research and medical care. Booth information and presenter schedules below.

 
 
 

Tamim Shaikh
Q&A with Tamim Shaikh
In recognition of April as Autism Awareness Month, the Global Down Syndrome Foundation held a Q&A with Dr. Tamim H. Shaikh, Associate Professor of Pediatrics at the University of Colorado Anschutz Medical Campus. Dr. Shaikh has received one of the inaugural Crnic Grand Challenge Grants to study the genetic modifiers of autism spectrum disorders in patients with Down syndrome.

 
 
 
 
 
 

Katie Shore
High School Senior Katie Shore Raises Awareness and Funds for Global Down Syndrome Foundation
We are continually impressed and humbled by the generosity, ingenuity and compassion of our donors. One recent example shines a light on how a high school student can make an adult-size impact.
Katie Shore of McConnellsburg High School in Pennsylvania raised more than $2,300 in five days for her senior project and donated the entire amount to the Global Down Syndrome Foundation! Inspired by her niece who has Down syndrome, Katie decided to raise money for Global and created a game that pitted each classroom in her school against the other.

 

Dr. Francis Hickey
Q&A with Dr. Francis Hickey
In recognition of Febuary as American Heart Month, the Global Down Syndrome Foundation held a Question & Answer session with Dr. Francis Hickey, the Medical Director at the Anna and John J. Sie Center for Down Syndrome at Children’s Hospital Colorado. Dr. Hickey has received one of the inaugural Crnic Institute Grand Challenge Grants, to study the pharmacokinetics of morphine in post-operative cardiac patients with Down syndrome.

 
 
 
 
 

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Linda Crnic Institute for Down Syndrome
The Leader in scientific research benefiting people with Down syndrome

Meet the Crnic Institute Supergroup 2013 Grant Recipients

V. Balasubramaniam, M.D.
Sleep apnea and Down syndrome
Examine the effect of sleep apnea on vascular stem cells in people with Down syndrome
Christopher Link, Ph.D.
Genetic understanding of Down syndrome
Determine which genes have altered expression due to Trisomy 21
James DeGregori, Ph.D.
Leukemia and Down syndrome
Study increase in leukemia incidence and other problems with blood cell production, including reduced immunity
Karl Pfenninger, M.D.
Cognition and Down syndrome
Study causes of intellectual disability associated with Down syndrome, specifically the APP protein
Robin Dowell, Ph.D.
Genetic understanding of Down syndrome
Understand how Trisomy 21 affects the behavior of key proteins involved in regulating expression
Tamim H. Shaikh, Ph.D.
Autism and Down syndrome
Research genetic modifiers of autism spectrum disorders in patients with Down syndrome
Joaquin Espinosa, Ph.D.
Genetic understanding of Down syndrome
Identify genes whose function is essential in trisomic cells yet dispensable in cells with only two copies of chromosome 21
Richard Spritz, M.D.
Autoimmune disorders and Down syndrome
Analyze autoimmunity genetics in Down syndrome — thyroid disease, celiac disease, type 1 diabetes and rheumatoid arthritis
Fran Hickey, M.D.
Anesthesia and Down syndrome
Provide information to improve management of post-operative pain and sedation in children with Down syndrome
Ding Xue, Ph.D.
Alzheimer’s disease and Down syndrome
Study the roles of presenilin and ubiquilin in developing treatments for Alzheimer’s disease in patients with Down syndrome
Kevin Jones, Ph.D.
Gene regulation and Down syndrome
Test whether increasing the abundance of the BDNF protein can prevent Down syndrome pathology in a mouse model
Michael Yeager, Ph.D.
Autoimmune disorders and Down syndrome
Understand immune system disturbances in individuals with Down syndrome and drive development of newer therapies
Matthew Kennedy, Ph.D.
Alzheimer’s disease and Down syndrome
Investigate how increased beta-amyloid production causes synapse loss in hope of finding targets for future therapies
Rui Yi, Ph.D.
Genetic understanding of Down syndrome
Determine the effect of gene dosage imbalance on activity in trisomic embryonic stem cells

Meet the full Supergroup